منابع مشابه
Substrate selectivity in glutamate-dependent acid resistance in enteric bacteria.
The bacterial antiporter GadC plays a central role in the glutamate (Glu)-dependent acid resistance system, which protects enteric bacteria against the extreme acidity of the human stomach. Upon acid shock, GadC imports Glu into the cytoplasm, where Glu decarboxylases consume a cytoplasmic proton, which ends up as a "virtual" proton in the decarboxylated product γ-aminobutyric acid (GABA) and i...
متن کاملSubstrate selectivity in arginine-dependent acid resistance in enteric bacteria.
To successfully colonize the human gut, enteric bacteria must activate acid resistance systems to survive the extreme acidity (pH 1.5-3.5) of the stomach. The antiporter AdiC is the master orchestrator of the arginine-dependent system. Upon acid shock, it imports extracellular arginine (Arg) into the cytoplasm, providing the substrate for arginine decarboxylases, which consume a cellular proton...
متن کاملChaperone-dependent mechanisms for acid resistance in enteric bacteria.
The extremely acidic environment of the mammalian stomach not only serves to facilitate food digestion but also acts as a natural barrier against infections of food-borne pathogens. Many pathogenic bacteria, such as enterohemorrhagic Escherichia coli, can breach this host defense and cause severe diseases. These pathogens have evolved multiple intricate strategies to overcome the bactericidal a...
متن کاملConserved amphiphilic feature is essential for periplasmic chaperone HdeA to support acid resistance in enteric bacteria.
The extremely acidic environment of the mammalian stomach (pH 1-3) represents a stressful challenge for enteric pathogenic bacteria, including Escherichia coli, Shigella and Brucella. The hdeA (hns-dependent expression A) gene was found to be crucial for the survival of these enteric bacteria under extremely low pH conditions. We recently demonstrated that HdeA is able to exhibit chaperone-like...
متن کاملEnteric Bacteria
Biochemical confirmation of salmonellae by conventional tube methods usually requires 2 to 3 days of incubation time preceded by preparation of tubed media and transfer of cultures. The principles of heavy inocula and increased substrate concentrations have been used by Sanders et al. (1) to speed up reaction times and thus reduce the time necessary in the laboratory for analysis. To characteri...
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ژورنال
عنوان ژورنال: Infection and Immunity
سال: 1993
ISSN: 0019-9567,1098-5522
DOI: 10.1128/iai.61.1.364-367.1993